If you’re like nearly 80 percent of U.S. adults, you already consume some kind of caffeinated beverage daily – but are you taking advantage of adaptogens?

You probably know about the energizing effects of caffeine, but more and more people are finding the benefits of using both caffeine and adaptogens together.

How do these two ingredients work together in the body? Here’s a little background on each:


Caffeine, when consumed at a moderate dose, does a great job at keeping you energized and alert. Because caffeine is a stimulant, it quickly results in wakefulness and helps fight fatigue (1).

On a molecular level, caffeine works because it’s similar to the neurotransmitter called adenosine. Throughout the day or when you’re lacking rest, adenosine builds up near certain receptors in the brain and signals the brain to slow down nerve activity. This, in turn, causes feelings of drowsiness and tiredness.

When you consume caffeine, it takes the place of adenosine on the receptors in the brain. But by keeping adenosine from signaling tiredness, caffeine has the opposite effect in speeding up nerve cells waking you up and improving focus.


Adaptogens are a variety of bioactive plant compounds that work in a completely different way than stimulants to improve physical and mental performance.

Unlike caffeine, adaptogens work by normalizing the body’s functions under stress (2-3). Adaptogens do this by specifically helping the body “adapt” (hence the name) to better resist the effects of a given stressor. These can range from physical or mental stressors such as athletic activity or a mental task like writing.

Recent studies have found that adaptogens reduce mental fatigue, improve physical endurance, and can aid recovery after intense physical activity (4-6).

Working Together in e+ Natural Energy Shot

Adaptogens are conveniently paired up with about 85 milligrams of naturally sourced caffeine from green tea and yerba mate in e+™ energy shots. These shots have recently been used in studies on athletic performance (7-8).

The caffeine and adaptogens in e+ work together so you can benefit from both for compounding energizing effects.

The combination with only a moderate dose of caffeine and a few grams of sugar from juice concentrates can result in a steady rise of energy. The effect can keep the typical “jitters” and subsequent crash as experienced from other energy shots at bay.

Isagenix also offers caffeine and adaptogens separately in the forms of Isagenix Coffee and Ionix® Supreme.

So there are plenty of options for how you choose to get your daily doses of each.


  1. Ribeiro JA, Sebastião AM. Caffeine and adenosine. J Alzheimers Dis. 2010;20 Suppl 1:S3-15. doi: 10.3233/JAD-2010-1379.
  2. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. 2009 Sep;4(3):198-219. Epub 2009 Sep 1.
  3. Panossian A, Wikman G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals (Basel). 2010 Jan; 3(1): 188–224. Published online 2010 Jan 19. doi: 3390/ph3010188
  4. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.
  5. Kuo J, Chen KW, Cheng IS, Tsai PH, Lu YJ, Lee NY. The effect of eight weeks of supplementation with Eleutherococcus senticosus on endurance capacity and metabolism in human. Chin J Physiol. 2010 Apr 30;53(2):105-11.
  6. Amagase H, Sun B, Borek C. Lycium barbarum (goji) juice improves in vivo antioxidant biomarkers in serum of healthy adults. Nutr Res. 2009 Jan;29(1):19-25. doi: 10.1016/j.nutres.2008.11.005.
  7. Ives SJ, Norton C, Miller V, Minicucci O, et al. Multi-modal exercise training and protein-pacing enhances physical performance adaptations independent of growth hormone and BDNF but may be dependent on IGF-1 in exercise-trained men. Growth Horm IGF Res. Oct; 24. DOI: http://dx.doi.org/10.1016/j.ghir.2016.10.002
  8. Arciero PJ, Ives SJ, Norton C, et al. Protein-Pacing and Multi-Component Exercise Training Improves Physical Performance Outcomes in Exercise-Trained Women: The PRISE 3 Study. Nutrients. 2016 Jun 1;8(6).

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